Fig. 3.1.

Human and mouse pancreas development. Pancreas developmental programs in humans and mice, top and bottom, respectively, are highly conserved, as shown in the panels correlating similar time points across species. Starting about 23 days after conception in humans (~CS11) and 8.5–9 days in mice (E8.5–E9) the dorsal pancreatic bud emerges from the endodermal gut tube. Several stages of development are depicted across each row demonstrating similar morphological changes occurring in both humans and mice over about 60 days in humans and 16.5 days in mice, at which point immature endocrine cells are present and producing hormones. Over the next few months in humans and weeks in mice, these endocrine cells mature as islets that contain the same cell types but in different ratios and distribution within the islet in each species