Fig. 3.3.

Molecular mechanisms of pancreas development in mice and humans. A selection of transcription factors and cell signaling pathways define the transition from gut endoderm to immature pancreas, which takes place in about 37 days in humans (CS labels in bold) and about 8 days in mice (E labels). While much is known about the cell signaling pathways early on, less is known about the key signaling events later in this development scheme (~E16.0–E16.5). VP represents the contribution of BMP signaling specifically to the ventral pancreatic bud, but not the dorsal bud, at this stage of development