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. 2021 Jun 3;10(1):1016–1023. doi: 10.1080/22221751.2021.1931465

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Epitope immunodominance of SARS-CoV-2 ORF8 protein in SARS-CoV-2-infected hamsters. (A–C) Hamsters were infected with SARS-CoV-2 virus (A). Antibodies agasint ORF8 protein (B) and N protein (C) in the sera of SARS-CoV-2-challenged hamsters at 0 (n = 20), 4 (n = 25), and 14 dpi (n=9). (D) Sera of SARS-CoV-2-infected hamsters at 14 dpi (n = 9) at 1:100 dilution were subjected to peptide-based IgG ELISA using peptide pools covering the entire ORF8 protein of SARS-CoV-2. Sera of naïve hamsters (n = 20) were assessed in parallel. OD values subtracted of cut-off values presented with negative values are plotted as zero. The cut-off for seropositivity was set as the mean value of control serum samples plus two times of standard deviation. The dotted lines represent cut-off values. Data were presented as mean ± standard deviation. *, p < .05; **, p < .01; ***, p < .001; ****, p < .0001.