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. 2021 Jun 3;36(1):1217–1229. doi: 10.1080/14756366.2021.1931165

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Effect of different concentrations of compounds 12, 13, 15 and 20 over the PaPhzSTm values (upper panel – A–D) and over the fraction on unfolded PaPhzS (lower panel – E–H) at 43 C. ΔTm was calculated in comparison to DMSO (control) and Kd values were calculated using DSFit software. Plots were generated with GraphPad Prism v.8.0. All data represent the mean ± SD from three independent experiments.