Table 1.
Summary of in vivo vaccination studies demonstrating Operational Taxonomic Unit (OTU) genotypes escape from commercial live anticoccidial vaccines.
| Trial | Vaccination | Challenge1 | No. | Log10 oocysts per chicken (+/− SEM) | Present (PCR confirmation) |
|---|---|---|---|---|---|
| 1 | None | Paracox® 8 | 2 | 5.08 (na) | |
| Paracox® 8 (x3) | Paracox® 8 | 2 | Nd | ||
| Paracox® 8 (x3) | Ng1[1]: A,N,T,x,y | 2 | 7.44 (na) | x, y | |
| Paracox® 8 (x3) | Ng2[1]: A,Ma,Mi,T,x,y,z | 2 | 7.49 (na) | A, x, y, z | |
| Paracox® 8 (x3) | Ng3[1]: A,B,Mi,N,T,x,y | 2 | 6.3 (na) | x, y | |
| 2 | None | Paracox® 8 | 6 | 5.38 (0.43)a | |
| Paracox® 8 (x3) | Paracox® 8 | 6 | ndb | ||
| None | Ng1[2]: x,y | 6 | 7.47 (0.35)c | x, y | |
| Paracox® 8 (x3) | Ng1[2]: x,y | 6 | 7.32 (0.32)c | x, y | |
| 3 | None | Paracox® 8 | 5 | 5.32 (0.38)a | |
| Paracox® 8 (x3) | Paracox® 8 | 5 | ndb | ||
| None | x (Nig) | 5 | 7.14 (0.42)c | x | |
| Paracox® 8 (x3) | x (Nig) | 5 | 7.11 (0.60)c | x | |
| X | x (Nig) | 5 | ndb | ||
| None | z (Nig) | 5 | 7.48 (0.65)c | z | |
| Paracox® 8 (x3) | z (Nig) | 5 | 7.53 (0.58)c | z | |
| Z | z (Nig) | 5 | ndb | ||
| 4 | None | z (Aus) | 10 | 6.71 (na) | z |
| MMAT+NB | z (Aus) | 10 | 6.64 (na) | z | |
| Z | z (Aus) | 10 | Nd |
na, not applicable; nd, none detected; A, Eimeria acervulina; B, Eimeria brunetti; Ma, Eimeria maxima; Mi, Eimeria mitis; N, Eimeria necatrix; P, Eimeria praecox (not represented); T, Eimeria tenella; x, OTUx; y, OTUy; z, OTUz.
Different superscript letters within a trial indicate statistically significant differences (P < 0.05).
1
Eimeria spp. and genotypes present in the starting dose are indicated.