KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, Peptides, and Recombinant Proteins
Propranolol hydrochloride	Sigma-Aldrich	Cat#P8688
Prazosin	Sigma-Aldrich	Cat#P7791
Atipamezole	Sigma-Aldrich	Cat#A9611
Evans blue	Sigma-Aldrich	Cat#E2129
TRITC-dextran	Sigma-Aldrich	Cat# T1287
Experimental Models: Organisms/Strains
Mouse strain: C57BL/6	Charles River Laboratories	Strain code: 027
Mouse strain: APPswe/PS1dE9 (APP/PS1)	The Jackson Laboratory	Stock No: 34829-JAX
Software and Algorithms
Fiji software	Freely available online	https://imagej.net/Fiji
MATLAB 9.3	MathWorks	https://www.mathworks.com/products/compiler/matlab-runtime.html
GraphPad Prism 8	GraphPad Software	https://www.graphpad.com/scientific-software/prism/