Table 1.
Summary of Cumulative Release of Voriconazole From Drug Loaded HAM in Each Group
| Time (h) | Group I | Group II | Group III | Group IV | Group V | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean±SEM (µg/ml) | Cumulative Amount (µg/ml) | Mean±SEM (µg/ml) | Cumulative Amount (µg/ml) | Mean±SEM (µg/ml) | Cumulative Amount (µg/ml) | Mean±SEM (µg/ml) | Cumulative Amount (µg/ml) | Mean±SEM (µg/ml) | Cumulative Amount (µg/ml) | |
| 0.5 | 106.6±9.4 | 106.6 | 107.1±18.8 | 107.1 | 159.7±7.4 | 159.7 | 183.3±10.2 | 183.3 | 172.1±15.5 | 172.1 |
| 1 | 132.9±13.4 | 239.5 | 131.1±29.8 | 238.2 | 140.5±8.5 | 300.2 | 173.3±14.0 | 356.6 | 166.9±7.1 | 339.0 |
| 2 | 146.7±13.7 | 386.2 | 145.3±19.2 | 383.5 | 138.1±12.9 | 438.3 | 161.1±11.3 | 517.7 | 143.5±4.7 | 482.5 |
| 3 | 156.3±17.8 | 542.6 | 146.7±29.8 | 530.3 | 131.8±11.3 | 570.1 | 157.0±11.4 | 674.7 | 140.0±5.7 | 622.5 |
| 4 | 151.2±19.3 | 693.8 | 173.1±34.1 | 703.4 | 124.4±9.2 | 694.5 | 154.0±11.9 | 828.8 | 139.4±18.9 | 762.0 |
| 5 | 146.5±23.7 | 840.3 | 172.7±36.6 | 876.1 | 146.5±5.1 | 841.0 | 144.8±13.2 | 973.6 | 132.4±5.7 | 894.3 |
| 6 | 135.0±22.8 | 975.3 | 153.8±33.4 | 1029.8 | 112.5±14.6 | 953.5 | 131.9±13.4 | 1105.5 | 125.4±12.1 | 1019.8 |
| 12 | 129.1±22.9 | 1104.4 | 141.1±31.0 | 1170.9 | 100.9±10.3 | 1054.4 | 120.5±13.3 | 1226.1 | 117.9±4.4 | 1137.6 |
| 24 | 129.4±20.4 | 1233.8 | 144.3±27.0 | 1315.2 | 98.2±10.0 | 1152.7 | 110.5±13.8 | 1336.6 | 105.3±6.2 | 1242.9 |
| 72 | 76.5±10.4 | 1310.3 | 80.2±15.8 | 1395.4 | 88.0±10.7 | 1240.7 | 88.5±7.1 | 1425.1 | 93.7±11.3 | 1336.7 |
| 120 | 70.2±11.9 | 1380.5 | 75.0±14.5 | 1470.4 | 83.4±11.2 | 1324.1 | 71.2±6.0 | 1496.3 | 75.4±6.6 | 1412.0 |
| 168 | 66.8±12.5 | 1447.4 | 70.2±14.6 | 1540.6 | 79.8±6.1 | 1403.9 | 63.8±4.0 | 1560.1 | 63.8±2.0 | 1475.8 |
| 336 | 60.3±9.6 | 1507.6 | 66.2±13.4 | 1606.8 | 63.4±0.4 | 1467.3 | 55.3±3.0 | 1615.4 | 58.9±2.4 | 1534.7 |
| 504 | 44.1±6.3 | 1551.7 | 51.1±9.4 | 1658.0 | 35.9±8.1 | 1503.2 | 44.6±3.7 | 1660.0 | 41.4±4.0 | 1576.2 |
| 672 | 25.2±4.8 | 1577.0 | 30.1±6.0 | 1688.0 | 28.5±5.9 | 1531.7 | 29.3±1.2 | 1689.3 | 26.6±5.7 | 1602.8 |
| 840 | 12.5±3.6 | 1589.5 | 8.3±0.4 | 1696.3 | 0.5±0.1 | 1532.2 | 1.7±0.3 | 1691.0 | 2.8±1.8 | 1605.6 |
Different groups represent different drug soaking times with 1% voriconazole. Group I (3 h); Group II (6 h); Group III (12 h); Group IV (24 h); and Group V (48 h). No significant difference was observed with different drug soaking times. Bold values represent the total cumulative amount of drug released up to the study period