Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 25;9:664843. doi: 10.3389/fcell.2021.664843

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Cao, Yang, Wang, Li and Nashun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Identification of the hub methylation marker genes in PCOS. (A) Scatterplots showing the comparison between transcriptome and the DNA methylome. Genes with significant changes in DNA methylation levels (abs change >0.2) and expression levels (abs log2 fold change >1) were defined as “methylation-affected genes.” Hypermethylation-affected downregulated genes were labeled in blue; Hypomethylation-affected upregulated genes were labeled in red. (B) Heatmap showing the module clustering of 94 methylation-affected upregulated genes by Pearson correlation coefficient. (C,D) Network diagrams showing interaction of genes in the two modules that were obtained in panel (B). Hub node genes were highlighted by yellow. The genes in the small networks are highly connected in the networks calculated by module mining.