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. 2021 May 25;9:664843. doi: 10.3389/fcell.2021.664843

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Copyright © 2021 Cao, Yang, Wang, Li and Nashun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The DNA methylation and miRNA coregulation profile in PCOS. (A) Venn diagram showing the genes that are coregulated by downregulated miRNAs and reduced DNA methylation in PCOS. (B) Coregulation of DNA methylation and miRNA in PCOS. The key molecular markers and pathways are labeled in different colors. The hollow box represents the signaling pathway where the marker genes are involved, and the solid box represents the genes that are coregulated by miRNA and DNA methylation.