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. 2021 Jun 7;9(1):e002038. doi: 10.1136/bmjdrc-2020-002038

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Egr-1 expression at the indicated time points in HG-treated or TGF-β1-treated HK2 cells. The Egr-1 mRNA (A) and Egr-1 protein (D) levels are determined at the indicated time points after HG treatment initiation. The Egr-1 mRNA (B) and Egr-1 protein (E) levels are determined at the indicated time points after TGF-β1 treatment initiation. The results are expressed as fold change over baseline (0 hour). Egr-1 expression in HK2 cells treated with LG, HG and TGF-β1. Levels of Egr-1 mRNA (C) and Egr-1 protein (F) are assessed in HK2 cells treated for 0.5 hour/1.5 hours with LG, HG, TGF-β1 and HG+TGF-β1, and HK2 cells treated with mannitol serve as an osmotic control. Values are mean±SD. *P<0.05 vs 0 hour, ^△P<0.01 vs 0 hour. Egr-1, early growth response factor 1; HG, high-glucose; LG, low-glucose; TGF-β1, transforming growth factor-β1.