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. 2021 Jun 8;16(6):e0252822. doi: 10.1371/journal.pone.0252822

Fig 2. Sensitivity to chemotherapeutic agents in ER-positive breast cancer cell lines and their tamoxifen-resistant sublines.

Fig 2

Sensitivity to 5-fluorouracil (a), paclitaxel (b), and doxorubicin (c) in wild-type (wt) and TAM-resistant MCF7 (A), T47D (B), and BT474 (C) cells were determined using the WST assay. Black lines with closed squares (■) indicate wild-type cells (wt-MCF7, wt-T47D, and wt-BT474), dotted lines with closed circles (●) indicate TAM-resistant sublines (MCF7/T, T47D/T, and BT474/T). Error bars represent standard deviations of the values obtained from triplicate experiments. Each experiment was independently performed and repeated at least three times, and one representative result is provided in the figures.