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. 2021 Jun 4;13:4483–4495. doi: 10.2147/CMAR.S300515

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© 2021 Liu et al.

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Ubenimex significantly restrains the migration and invasion potential of GC cells. (A–D) Wound healing assays showing the decreased healing rate of the scratch wound in MGC-803, SGC-7901, BGC-823 and MKN-28 human gastric cells. Representative images are shown. (E and F) The column graph displays a summary of the healing rates. (G and I) Transwell invasion or migration assay with 0.12 mg/mL or 0.25 mg/mL of Ubenimex for MGC-803, SGC-7901, BGC-823 and MKN-28 human gastric cells. Photomicrographs of invaded or migrated tumor cells are shown. Bar =100 µm. (H and J) Column graph of the number of invaded or migrated cells. (K–N) Western blot analyses of E-cadherin, N-cadherin, and Vimentin expression in MGC-803, SGC-7901, BGC-823 and MKN-28 human gastric cells. The column graph shows the relative grayscale value of each band compared with that of β‑actin. *P<0.05, **P<0.01, and ***P<0.001.