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. 2021 Jun 4;13:4483–4495. doi: 10.2147/CMAR.S300515

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© 2021 Liu et al.

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Ubenimex inhibits the invasion and migration of GC cells in which CD13 reduction is essential. (A) Western blot analyses of CD13 expression in MGC-803, SGC-7901, BGC-823 and MKN-28 human gastric cells. (B) The column graph shows the relative grayscale value of each band compared with that of β‑actin. (C and E) Transwell invasion and migration assays of MGC-803, SGC-7901, BGC-823 and MKN-28 human gastric cells treated with 0.12 mg/mL or 0.25 mg/mL of Ubenimex after transfection of CD13 overexpression plasmids. Bar = 100 µm. Photomicrographs of invaded or migrated tumor cells. (D and F) Column graph of the number of invaded or migrated cells. *P<0.05, **P<0.01 and ***P<0.001.