Table 2.

Comparison of the methods reported in the literature for pregabalin.

Method	SV (ml)	E T	LOD	%RSD	RR	Ref
LLE (manual)	50	10 min	4.8 ng/mL	0.17	99.5–101	[44]
LLE (ultrasonication)	50	∼15 min	66.9 ng/mL	0.068–0.167	97.12–98.86	[13]
LLE (manual)	15	3 min	1 ng/mL	11.4%.	69.8–72%	[45]
PME	20	2 min	0.03 ng/mL	6.8%	90–92	Current study

SV: sample volume (mL). ET: extraction time (min). LOD: limit of detection (ng/mL). RSD: relative standard deviation (%). RR: relative recovery (%).