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Specificity of the Sanger sequencing assay for TERTp mutations. Shown are representative sequences of wild-type TERTp. (a) Wild-type TERTp as detected by sense sequences. (b) Wild-type TERTp as detected by antisense sequences. Note that the arrowhead points to the nucleotide C228 site of TERTp. TERTp: the promoter region of the telomerase reverse transcriptase gene.
