Table 4.
Correlations between clinicopathological characteristics and the status of TERTp mutations.
| Total | IDH | P value | MGMT | P value | |||
|---|---|---|---|---|---|---|---|
| Mut | Wt | M | U | ||||
| n = 147 (%) | n = 76 (%) | n = 71 (%) | n = 108 (%) | n = 39 (%) | |||
| Sex | 0.505 | 0.707 | |||||
| Male | 84 (57.1) | 41 (53.9) | 43 (60.6) | 63 (58.3) | 21 (53.8) | ||
| Female | 63 (42.9) | 35 (46.1) | 28 (39.4) | 45 (41.7) | 18 (46.2) | ||
| Age (years) | 0.005∗ | 0.257 | |||||
| <45 | 70 (47.6) | 42 (55.3) | 28 (39.4) | 50 (46.3) | 20 (51.3) | ||
| 45-60 | 59 (40.1) | 31 (40.8) | 28 (39.4) | 47 (43.5) | 12 (30.8) | ||
| ≥60 | 18 (12.2) | 3 (3.9) | 15 (21.1) | 11 (10.2) | 7 (17.9) | ||
| Tumor location | <0.001∗ | 0.022∗ | |||||
| Frontal | 91 (61.9) | 58 (76.3) | 33 (46.5) | 73 (67.6) | 18 (46.2) | ||
| Others | 56 (38.1) | 18 (23.7) | 38 (53.5) | 35 (32.4) | 21 (53.8) | ||
| Histology | <0.001∗ | 0.009∗ | |||||
| DA | 37 (25.2) | 20 (26.3) | 17 (23.9) | 22 (20.4) | 15 (38.5) | ||
| AA | 15 (10.2) | 6 (7.9) | 9 (12.7) | 14 (13.0) | 1 (2.6) | ||
| AO | 24 (16.3) | 16 (21.1) | 8 (11.3) | 20 (18.5) | 4 (10.3) | ||
| OA | 6 (4.1) | 4 (5.3) | 2 (2.8) | 2 (1.9) | 4 (10.3) | ||
| O | 28 (19.0) | 22 (28.9) | 6 (8.5) | 24 (22.2) | 4 (10.3) | ||
| GBMs | 37 (25.2) | 7 (9.2) | 29 (40.8) | 26 (24.1) | 11 (28.2) | ||
| Pathologic stage | <0.001∗ | 0.286 | |||||
| Grade II-III | 109 (74.1) | 67 (88.2) | 42 (59.2) | 83 (76.1) | 26 (66.7) | ||
| Grade IV | 38 (25.9) | 9 (11.8) | 29 (40.8) | 25 (22.9) | 13 (33.3) | ||
| Ki-67 | 0.011∗ | 1.000 | |||||
| <15% | 89 (60.5) | 54 (71.1) | 35 (49.3) | 65 (60.2) | 24 (61.5) | ||
| ≥15% | 58 (39.5) | 22 (28.9) | 36 (50.7) | 43 (39.8) | 15 (38.5) | ||
| MGMT promoter | 0.003∗ | — | |||||
| Methylated | 108 (73.5) | 64 (84.2) | 44 (62.0) | — | — | ||
| Unmethylated | 39 (26.5) | 12 (15.8) | 27 (38.0) | — | — | ||
| TERT promoter | 0.312 | 0.088 | |||||
| Mutation | 59 (40.1) | 34 (44.7) | 25 (35.2) | 48 (44.4) | 11 (28.2) | ||
| Wild type | 88 (59.9) | 42 (55.3) | 46 (64.8) | 60 (55.6) | 28 (71.8) | ||
TERTp: the promoter region of the telomerase reverse transcriptase gene; IDH: isocitrate dehydrogenase; MGMT: O6-methylguanine-DNA methyltransferase; Mut: mutation; Wt: wild-type; M: methylated; U: unmethylated; DA: diffuse astrocytoma; AA: anaplastic astrocytoma; AO: anaplastic oligodendroglioma; OA: oligoastrocytoma; O: oligodendroglioma; GBMs: glioblastomas. P value was calculated by the Pearson chi-square test or the 2-tailed Fisher's exact test. ∗Statistically significant: P < 0.05.