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. 2021 Jun 4;17:1811–1823. doi: 10.2147/NDT.S309065

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© 2021 Wang et al.

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Effect of Par C on histopathological change of the brain tissue after MCAO. Scale bar = 50 µm, with magnification 200×. The sham group exhibited the normal morphologic features of neurons. The MCAO group exhibited the presence of vacuolated interspaces and disordered brain neuronal arrangement. Par C and Eda alleviated the injury of neurons in the MCAO group. MCAO+LPar: 25 mg/kg body weight Par C treatment dose; MCAO+MPar: 50 mg/kg body weight Par C treatment dose; MCAO+HPar: 100 mg/kg body weight Par treatment dose; MCAO+Eda: 3 mg/kg body weight Eda treatment dose.

Abbreviations: Par C, Parishin C; MCAO, middle cerebral artery occlusion; Eda: edaravone.