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. 2021 Jun 4;17:1811–1823. doi: 10.2147/NDT.S309065

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© 2021 Wang et al.

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Par C down-regulated the inflammation gene expression in the brain tissue after MCAO. The mRNA expression levels of TNF-α (A), IL-6 (B), IL-1β (C), and NF-κB (D) level in brain tissue were measured by RT-qPCR. Data were shown as mean ± SD (n = 6). ***P < 0.001, **P < 0.01, no significant difference (ns). MCAO+LPar: 25 mg/kg body weight Par C treatment dose; MCAO+MPar: 50 mg/kg body weight Par C treatment dose; MCAO+HPar: 100 mg/kg body weight Par C treatment dose; MCAO+Eda: 3 mg/kg body weight Eda treatment dose.

Abbreviations: SD, standard deviation; Par C, Parishin C; MCAO, middle cerebral artery occlusion; TNF-α, tumor necrosis factor-α; IL-6, interleukin-6; IL-1β, interleukin-1β.