Figure 2.

Circuitry involved in temporal association memory. A) The pyramidal cells of MECIII project directly to distal dendrites of CA1 pyramidal cells, while pyramidal cell clusters in ECIII project to interneurons in SL. B) this interplay between excitatory ECIII and inhibitory action driven ECII CalB⁺ inputs in CA1 tightly regulates temporal encoding, along with input from the medial septum (MS) resulting in a temporal sequence, and a refined temporal association memory. The temporal sequence can be seen in the sequential activation of individual neurons at a specific point in time within a larger time interval, with the total population covering the entirety of the interval period.