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. 2021 May 3;53(6):925–934. doi: 10.1038/s41588-021-00851-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Numbers of devAS cassette exons with each of the four patterns are shown for all organs and species. Patterns are shown in the order indicated for kidney (that is, up, down, up-down and down-up). b, Same as (a) but samples were rarefied before the pattern analysis to make their distribution across development more even. For each species and organ, we split the whole developmental span (in a logarithmic scale of days post-conception, DPC) into 10 equally sized bins. Then we calculated the minimal number of samples per bin and randomly took as many (but not less than one) samples from each bin. c, Same as (a) but a rank of the developmental stage was used instead of the log(DPC) for the pattern analysis. The analyses in (b) and (c) were designed to test the dependence of the pattern analysis on the evenness of the distribution of samples across development.