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Anti-Toxoplasma activity, Median toxicity dose, Therapeutic index and molecular docking results for the best 4-thiazolidinone compounds.
| Molecule | IC50 (μM) |
TD50 (μM) |
TI | Affinity TgCDPK1 (kcal/mol) |
Affinity TgROP18 (kcal/mol) |
||
|---|---|---|---|---|---|---|---|
| A. Vina | Smina | A. Vina | Smina | ||||
| 1B | 0.46 | 60 | 128 | −7.16 ± 0.03 | −7.26 ± 0.03 | −6.30 ± 0.00 | −6.40 ± 0.10 |
| 2B | 0.20 | 206 | 1000 | −7.90 ± 0.00 | −7.90 ± 0.00 | −6.56 ± 0.03 | −6.60 ± 0.00 |
| 3B | 0.66 | 125 | 188 | −7.63 ± 0.12 | −7.93 ± 0.23 | −6.96 ± 0.03 | −7.10 ± 0.00 |
