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. 2021 Jun 8;116(1):40. doi: 10.1007/s00395-021-00881-9

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© The Author(s) 2021, corrected publication 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — sEVs from hypoxic MSCs increase cerebral microvascular endothelial cell migration. Relative number of migrating hCMEC/D3 cells, determined in a modified Boyden chamber transwell migration assay, after exposure to different concentrations of A sEVs obtained from MSC culture media that contain platelet lysates (sEV_platelet), B sEVs obtained from MSCs (

source 41.5) cultured under ‘normoxic’ conditions (21% O₂; sEV_normoxic) or C sEVs obtained from MSCs (source 41.5) cultured under hypoxic conditions (1% O₂; sEV_hypoxic). In D, representative microphotographs for hCMEC/D3 cells exposed to control conditions or sEVs at a 50 µg/mL concentration are shown. Data are mean ± SD values (n = 9 independent experiments). *p < 0.05, **p < 0.01, ***p < 0.001 compared with control. Scale bars: 125 µm in D