Table 6.

Insulins that target hepatic lipid and glucose metabolism

Drug	Mechanism of action	Mode of administration	Regulatory status	Clinical effect					References
				Steatosis	Fibrosis markers	Hepatic enzymes	HbA1c	Insulin resistance
Peglispro	Insulin	SC	Interrupted	↑	NA	=	↓	–	[108]
Glargine	Insulin	SC	Phase IV	=	NA	=	↓	–	[68, 79]
Glargine	Insulin	SC	Phase IV	↓	NA	=	↓	–	[71, 80, 107, 108]

SC, subcutaneous injection