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. 2021 Apr 29;64(7):1626–1641. doi: 10.1007/s00125-021-05453-z

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© The Author(s) 2021

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Fig. 2 — Potential TLOs in preclinical human donors with type 1 diabetes. Representative images of a double-aAb⁺ donor (no. 6197) with insulin-positive inflamed islet stained for PLM, insulin and CD45 (a) or MECA79, PLM and CD45 (b). Arrows mark the disruption of peri-islet BM in (a) and the MECA79⁺ HEVs in (b). Arrowheads point to MECA79⁻ vessels. Scale bars, 100 μm (a) and 50 μm (b). ac, acini; fa, fat; is, islet