Fig. 6.
Comparison of fibroblastic reticular cell markers in pancreatic TLOs in NOD mouse and human type 1 diabetes samples. (a, c) Immunofluorescence staining of inflamed human pancreas (donor no. 6325) for collagen III, PDGFrβ and CD45 (a) or collagen III, podoplanin and PLM (c). (b, d) Immunofluorescence staining of NOD mouse pancreases for PLM and PDGFrβ (b) or podoplanin (d). Arrows mark accumulation of FRCs at site of inflammation. Scale bars, 100 μm. Coll, collagen; is, healthy part of the islet