Table 1.
Clinical characteristics of the organ donors
| Donor characteristic | Donor no. | Age (years) | Sex | Age at type 1 diabetes diagnosis (years) | Diabetes duration (years) | Antibody status | Insulitis | C-peptide (nmol/l) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GADA | IA-2A | ZnT8A | mIAA | ||||||||
| Non-diabetic aAb− (n = 5) | nPOD 6098 | 17.8 | M | n/a | n/a | – | – | – | – | – | 0.46 |
| nPOD 6230 | 16 | M | n/a | n/a | – | – | – | – | – | 1.72 | |
| nPOD 6339 | 23.3 | M | n/a | n/a | – | – | – | – | – | 3.49 | |
| nPOD 6335 | 18.8 | M | n/a | n/a | – | – | – | – | – | 2.93 | |
| nPOD 6430 | 27.1 | M | n/a | n/a | – | – | – | – | – | 3.68 | |
| Non-diabetic single aAb+ (n = 7) | nPOD 6027 | 18.8 | M | n/a | n/a | – | – | + | – | – | n/a |
| nPOD6123 | 23.2 | F | n/a | n/a | + | – | – | – | – | 0.66 | |
| nPOD6151 | 30 | M | n/a | n/a | + | – | – | – | – | 1.81 | |
| nPOD6181 | 31.9 | M | n/a | n/a | + | – | – | – | – | 0.19 | |
| nPOD6301 | 26 | M | n/a | n/a | + | – | – | – | – | 1.29 | |
| nPOD 6310 | 28 | F | n/a | n/a | + | – | – | – | + | 3.48 | |
| nPOD 6314 | 21 | M | n/a | n/a | + | – | – | – | – | 0.49 | |
| Non-diabetic multiple aAb+ (n = 6) | nPOD 6080 | 69.2 | F | n/a | n/a | + | – | – | + | – | 0.60 |
| nPOD 6158 | 40.3 | M | n/a | n/a | + | – | – | + | – | 1.85 | |
| nPOD 6167 | 37 | M | n/a | n/a | – | + | + | – | – | 1.79 | |
| nPOD 6197 | 22 | M | n/a | n/a | + | + | – | – | + | 5.78 | |
| nPOD 6267 | 23 | F | n/a | n/a | + | + | – | – | + | 5.49 | |
| nPOD 6450 | 22 | F | n/a | n/a | + | – | + | – | + | 1.80 | |
| Donors with type 1 diabetes (n = 24) | nPOD 6362 | 24.9 | M | 24.9 | 0 | + | – | – | – | + | 0.12 |
| nPOD 6228 | 18 | M | 18 | 0 | + | + | + | – | + | 0.03 | |
| EADB E405 | 8 | F | 7.98 | <0.019 | n/a | n/a | n/a | n/a | + | n/a | |
| EADB SC115 | 1.25 | F | 1.24 | 0.008 | n/a | n/a | n/a | n/a | + | n/a | |
| EADB E124B | 17 | M | 16.98 | 0.02 | n/a | n/a | n/a | n/a | + | n/a | |
| EADB E308 | 3 | F | 2.92 | 0.08 | n/a | n/a | n/a | n/a | + | n/a | |
| nPOD6209 | 5 | F | 4.75 | 0.25 | – | + | + | + | + | 0.03 | |
| nPOD 6414 | 23.1 | M | 22.67 | 0.43 | + | – | + | +a | + | 0.05 | |
| nPOD 6247 | 24 | M | 23.4 | 0.6 | – | – | – | +a | + | 0.15 | |
| nPOD 6052 | 12 | M | 11 | 1 | + | – | – | – | + | 0.05 | |
| nPOD 6224 | 21 | F | 19.5 | 1.5 | – | – | – | – | + | <0.01 | |
| nPOD 6342 | 14 | F | 12 | 2 | + | – | – | +a | + | 0.08 | |
| nPOD 6371 | 12.5 | F | 10.5 | 2 | + | + | + | +a | + | 0.03 | |
| nPOD 6396 | 17.1 | F | 15.1 | 2 | – | – | – | – | + | 0.01 | |
| nPOD 6195 | 19.3 | M | 14.3 | 5 | + | + | + | +a | + | 0.01 | |
| nPOD 6212 | 20 | M | 15 | 5 | + | – | – | – | + | 0.01 | |
| nPOD 6243 | 13 | M | 8 | 5 | – | – | – | +a | + | 0.13 | |
| nPOD 6306 | 19 | M | 14 | 5 | – | – | – | +a | + | 0.01 | |
| nPOD 6325 | 20 | F | 14 | 6 | + | + | – | +a | + | 0.04 | |
| nPOD 6070 | 22.6 | F | 15.6 | 7 | + | – | – | +a | + | 0.01 | |
| nPOD 6245 | 22 | M | 15 | 7 | + | + | – | – | + | 0.01 | |
| nPOD 6302 | 38.5 | M | 6 | 32.5 | – | – | – | – | – | 0.05 | |
| nPOD 6085 | 71 | F | 8 | 63 | – | – | – | +*a | – | 0.01 | |
| nPOD 6086 | 89 | F | 5 | 84 | – | – | – | – | – | 0.01 | |
aIf the individuals have been on exogenous insulin for more than 10 days the mIAA is not a reliable marker for autoimmunity
F, female sex; M, male sex; mIAA, micro IAA