Table 3.
Distribution of pancreatic TLOs within type 1 diabetes donors
| Donor no. | Age of onset (years) | Disease duration (years) | No. of islets examined | Phase 0 islets (insulin+ islets, no insulitis) | Phase 1 islets (insulin+ islets with insulitis) | Phase 2 islets (insulin− islets with insulitis) | Phase 3 islets (insulin− islets, no insulitis) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Without TLOs | With TLOs | % with TLOs | Without TLOs | With TLOs | % with TLOs | Without TLOs | With TLOs | % with TLOs | Without TLOs | With TLOs | % with TLOs | ||||
| Donors with insulitis and TLOS with compartmentalised T cells and B cells | |||||||||||||||
| nPOD 6362 | 24.90 | 0 | 255 | 0 | 0 | n/a | 110 | 5 | 4.35 | 75 | 0 | 0.00 | 65 | 0 | 0.00 |
| EADB SC115 | 1.24 | 0.01 | 111 | 1 | 0 | 0.00 | 6 | 4 | 40 | 1 | 1 | 50 | 98 | 0 | 0.00 |
| EADB E124B | 16.98 | 0.02 | 56 | 33 | 0 | 0.00 | 5 | 3 | 37.50 | 0 | 0 | n/a | 15 | 0 | 0.00 |
| EADB E308 | 2.92 | 0.08 | 125 | 65 | 0 | 0.00 | 4 | 3 | 42.86 | 0 | 0 | n/a | 53 | 0 | 0.00 |
| Mean | 11.51 | 0.03 | 136.75 | 24.75 | 0.00 | 0.00 | 31.25 | 3.75 | 31.18 | 19.00 | 0.25 | 12.50 | 57.75 | 0.00 | 0.00 |
| SD | 11.37 | 0.03 | 84.27 | 30.90 | 0.00 | 0.00 | 52.51 | 0.96 | 18.02 | 37.34 | 0.50 | 25 | 34.27 | 0.00 | 0.00 |
| Donors with insulitis and TLOs with intermixed T cells and B cells | |||||||||||||||
| EADB E405 | 7.98 | 0.02 | 71 | 32 | 0 | 0.00 | 14 | 1 | 6.67 | 0 | 0 | n/a | 24 | 0 | 0.00 |
| nPOD6209 | 4.75 | 0.25 | 23 | 4 | 0 | 0.00 | 5 | 1 | 16.67 | 8 | 0 | 0.00 | 5 | 0 | 0.00 |
| nPOD 6052 | 11 | 1 | 77 | 0 | 0 | n/a | 22 | 4 | 15.38 | 9 | 1 | 10.00 | 41 | 0 | 0.00 |
| nPOD 6342 | 12 | 2 | 53 | 0 | 0 | n/a | 10 | 1 | 9.09 | 22 | 0 | 0.00 | 20 | 0 | 0.00 |
| nPOD 6371 | 10.50 | 2 | 48 | 2 | 0 | 0.00 | 37 | 6 | 13.95 | 2 | 1 | 33.33 | 0 | 0 | n/a |
| nPOD 6195 | 14.30 | 5 | 256 | 0 | 0 | n/a | 0 | 0 | n/a | 57 | 6 | 9.52 | 193 | 0 | 0.00 |
| nPOD 6325 | 14 | 6 | 221 | 99 | 0 | 0.00 | 96 | 5 | 4.95 | 14 | 1 | 6.67 | 6 | 0 | 0.00 |
| nPOD 6070 | 15.6 | 7 | 84 | 33 | 0 | 0.00 | 35 | 6 | 14.63 | 6 | 0 | 0.00 | 4 | 0 | 0.00 |
| Mean | 11.27 | 2.91 | 104.13 | 21.25 | 0.00 | 0.00 | 27.38 | 3.00 | 10.17 | 14.75 | 1.13 | 7.44 | 36.63 | 0.00 | 0.00 |
| SD | 3.58 | 2.71 | 85.61 | 34.48 | 0.00 | 0.00 | 30.75 | 2.51 | 5.95 | 18.41 | 2.03 | 11.36 | 64.64 | 0.00 | 0.00 |
| Donors with insulitis and without TLO | |||||||||||||||
| nPOD 6228 | 18 | 0 | 36 | 0 | 0 | n/a | 24 | 0 | 0.00 | 10 | 0 | 0.00 | 2 | 0 | 0.00 |
| nPOD 6414 | 22.67 | 0.43 | 87 | 2 | 0 | 0.00 | 27 | 0 | 0.00 | 35 | 0 | 0.00 | 23 | 0 | 0.00 |
| nPOD 6247 | 23.4 | 0.6 | 87 | 0 | 0 | n/a | 4 | 0 | 0.00 | 38 | 0 | 0.00 | 45 | 0 | 0.00 |
| nPOD 6224 | 19.5 | 1.5 | 81 | 3 | 0 | 0.00 | 5 | 0 | 0.00 | 25 | 0 | 0.00 | 48 | 0 | 0.00 |
| nPOD 6396 | 15.1 | 2 | 77 | 3 | 0 | 0.00 | 27 | 0 | 0.00 | 25 | 0 | 0.00 | 22 | 0 | 0.00 |
| nPOD 6212 | 15 | 5 | 136 | 9 | 0 | 0.00 | 5 | 0 | 0.00 | 22 | 0 | 0.00 | 100 | 0 | 0.00 |
| nPOD 6243 | 8 | 5 | 64 | 0 | 0 | n/a | 5 | 0 | 0.00 | 28 | 0 | 0.00 | 31 | 0 | 0.00 |
| nPOD 6306 | 14 | 5 | 28 | 6 | 0 | 0.00 | 8 | 0 | 0.00 | 3 | 0 | 0.00 | 11 | 0 | 0.00 |
| nPOD 6245 | 15 | 7 | 134 | 0 | 0 | n/a | 0 | 0 | n/a | 20 | 0 | 0.00 | 99 | 0 | 0.00 |
| Mean | 16.74 | 2.94 | 81.06 | 2.56 | 0.00 | 0.00 | 11.67 | 0.00 | 0.00 | 22.89 | 0.00 | 0.00 | 42.33 | 0.00 | 0.00 |
| SD | 4.76 | 2.56 | 37.07 | 3.17 | 0.00 | 0.00 | 10.98 | 0.00 | 0.00 | 11.07 | 0.00 | 0.00 | 35.53 | 0.00 | 0.00 |