Table 7.

Phosphorylation status of proteins in the FOXO signaling pathway of liver at 15 d of broiler chickens fed control or diets supplemented with a complex of biofactors and antioxidants undergoing early life stress.

Human Ortholog Uniprot number	Protein name	Phosphorylation status	Function
Q96EB6	SIRT1	-	+
P36897	TGF-B receptor	+	+
Q7L0×0	TLR7/8	+	unknown
P04040	Catalase (Y231, 386)	-	+
Q60591	NFAT	+	+
Q13131	AMPK	+	+
P45985	JNKK	+	+
P05412	AP-1	+	+
P46108	P38	-	+
Q00653	NF-kB	-	altered
P40189	IL-6	+	altered
P29460	IL-12	-	unknown
Q5VWK5	IL-23	+	unknown
P58753	TIRAP	-	+
P40763	STAT3	-	+
Q9UKE5	TRAF2	-	+
Q99683	ASK1	+	+

The phosphorylation status of the proteins found upstream or downstream of FOXO. The phosphorylation status of each significant protein in the jejunum at 15 d was determined by entering the respective Uniprot accession into phosphosite database (Hornbeck et al., 2015), finding the annotation of the site of interest and accounting for the phosphorylation fold change (increased or decreased) of that site.