Table 2.

MRI Analyses

Ratio	Gray Matter Index	Brain Region	F Value	β Estimate	Standard Error	P value
Kyn/5-HT	Sub-Cortex and Archiocortex Volumes	Hippocampus	8.70	−5.30	1.80	0.003
		Putamen	0.43	−1.51	2.30	0.511
		Caudate	0.09	−0.54	1.84	0.769
		Amygdala	0.41	−0.46	0.71	0.524
	Neocortex  Cortical Thickness	Superior Frontal Gyrus	12.1	−1.4E-3	4.0E-4	0.001
		Caudal Anterior Cingulate Gyrus	6.34	−1.3E-3	5.2E-4	0.012
		Medial Orbital Frontal Gyrus	12.1	−1.3E-3	3.7E-4	0.001
		Lateral Orbital Frontal Gyrus	10.1	−1.2E-3	3.7E-4	0.002
		Caudal Middle Frontal Gyrus	8.04	−1.1E-3	4.0E-4	0.005
		Rostral Middle Frontal Gyrus	9.16	−1.0E-3	3.3E-4	0.003
Kyn/TRP	Sub-Cortex and Archiocortex Volumes	Hippocampus	3.40	−4383	2379	0.066
		Putamen	0.18	−1279	3033	0.673
		Caudate	0.05	−545	2429	0.823
		Amygdala	0.60	−730	942	0.439
	Neocortex Cortical Thickness	Superior Frontal Gyrus	0.95	−0.52	0.53	0.330
		Caudal Anterior Cingulate Gyrus	1.00	0.69	0.69	0.318
		Medial Orbital Frontal Gyrus	1.10	−0.52	0.50	0.295
		Lateral Orbital Frontal Gyrus	0.11	−0.16	0.49	0.738
		Caudal Middle Frontal Gyrus	0.01	0.48	0.54	0.929
		Rostral Middle Frontal Gyrus	0.52	−0.31	0.44	0.472

Brain regions implicated in Region of Interest analyses examining the relationship between either Kyn/5-HT or Kyn/TRP ratios and less gray matter in sub-cortical volumes or thickness of the neocortex. Kyn = kynurenine. TRP = tryptophan. Please note that Beta values are large for Kyn/TRP because values are in the decimal range.