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. Author manuscript; available in PMC: 2022 Jun 7.
Published in final edited form as: Dev Cell. 2021 May 18;56(11):1646–1660.e5. doi: 10.1016/j.devcel.2021.04.027

Figure 5: Sox9 mediates mucous metaplasia upon Kdr loss.

Figure 5:

(A) Sox9 lineage-labeled cells include a limited number of club cells in the proximal airways and ciliated cells in the distal airways. (B and C) Kdr deletion leads to Sox9 expression in the metaplastic mucous cells of Shh-Cre;Kdrloxp/loxp mutants following NAPH treatment (n=3). (D and E) Sox9 is expressed in the airway mucous cells of Scgb1a1-CreER;Kdrloxp/loxp mutants following NAPH challenge (n=3). (F and G) Sox9 deletion attenuates mucous metaplasia of the regenerated airway epithelium in Scgb1a1-CreER;Kdrloxp/loxp;Sox9loxp/loxp mutants (n=4). Data represent mean ± s.e.m. ns: no significant; **p<0.01; ***p<0.001; statistical analysis by unpaired two-tailed Student’s t-test. Scale bar: 50 μm. See also Figure S5.