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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Biol Psychiatry. 2020 Dec 9:S0006-3223(20)32108-9. doi: 10.1016/j.biopsych.2020.11.022

Figure 5.

Figure 5.

Sex-differences in functional enrichment following cohabitation with an opposite-sex partner in prairie voles. Enrichment map depicting the clusters of differentially modulated pathways between male and female prairie voles at baseline (SN) and following 24 hrs (24H) or 3 weeks (3W) of cohabitation, identified by gene-set enrichment analyses. The area of each node, representing a gene-set (functional pathway), corresponds to the number of genes of the gene-set it contains, and its color depicts the direction of enrichment (red: female-biased, blue: male-biased) with the color intensity representing the enrichment score, either in the SN, (top right sector), 24H (bottom sector), or 3W (top left sector) datasets. As a result, a gene-set with different colors between its three sectors display a change in sex-bias following cohabitation with an opposite-sex partner, whereas a gene-set with three similarly-colored sectors show the same sex-bias regardless of the cohabitation status. Edge thickness is proportional to the number of genes overlapping between the two connected nodes.