Table 2.

Linear regression analysis of the relationship between respective wGRSs (European-ancestry specific, African-ancestry specific, predicted log-NMR calculated from the respective ancestry specific wGRSs, and a cross-ancestry specific) and log-transformed NMR in different ancestral populations in the PNAT2 and KIS3 clinical trials (i.e. training sets for AFR and EUR wGRSs). Values represent unique variance explained by the wGRS. P<0.001 unless otherwise indicated.

	Variance uniquely explained by wGRS
Predictor	AFR Training Set PNAT2+KIS3 (N=954)	EUR Training Set PNAT2 (N=933)	Merged AFR+EUR Training Set PNAT2+KIS3 (N=1887)
AFR wGRS	0.324	0.200	0.300
EUR wGRS	0.182	0.338	0.261
Predicted log-NMR (AFR or EUR wGRS)	-	-	0.359
Cross-ancestry wGRS	0.347	0.250	0.332