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. 2021 Jan 4;13:35. doi: 10.1007/s40820-020-00561-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic illustration of light-triggered clustered polymeric vesicles with self-supplied oxygen and tissue penetrability for potent PDT against hypoxic PCa tumor. b Penetration profiles of CC-PAMAM after HC@P1-Vesicle treatment with or without 805/660 irradiation in multicellular tumor spheroids. The imaging was conducted at 2-h postirradiation using CLSM. c Hypoxia of BxPC-3 tumor treated with C@P1-Vesicle or HC@P1-Vesicle using a hypoxia-specific probe pimonidazole (hypoxyprobe-1 plus kit). HC@P1-Vesicle: H₂O₂ and CC-PAMAM-loaded ROS-responsive P1 polymeric vesicles. C@P1-Vesicle: CC-PAMAM-loaded P1 polymeric vesicles without H₂O₂.

Reproduced from Ref. [42] with permission. Copyright © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim