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. 2021 May 26;8:658908. doi: 10.3389/fcvm.2021.658908

Figure 1.

Figure 1

(A) DNA sequencing of ataxia-telangiectasia-mutated (ATM) gene with different genotypes of single nucleotide polymorphism (SNP) rs189037. (B) ATM promoter region contains two SacII restriction enzyme sites, and one of them is present in SNP rs189037 (C/T) only when T → C institution at nucleotide 116 occurs. (C) Amplification products (287 bp) of ATM gene stained with gelgreen on a 1% agarose gel. (D) Polymerase chain reaction products digested with SacII and stained with silver nitrate on a 20% polyacrylamide gel. (E) Cardiac structure shown by ultrasound in centenarians with different genotypes of SNP rs189037. (F) Cardiac structure shown by ultrasound in middle-aged and elderly participants with different genotypes of SNP rs189037. (G) Median [maximum (Max), minimum (Min)] of cardiac structure and function in centenarians with different genotypes of SNP rs189037. (H) Mean [standard deviation (SD)] of cardiac structure and function in centenarians with different genotypes of SNP rs189037. (I) Median [maximum (Max), minimum (Min)] of cardiac structure and function in middle-aged and elderly participants with different genotypes of SNP rs189037. (J) Mean [standard deviation (SD)] of cardiac structure and function in middle-aged and elderly participants with different genotypes of SNP rs189037.