Table 6.
Associations of cardiac structure and function with different genotypes of rs189037 in the middle-aged and elderly.
| Characteristics | TT/CT | TT/CC | TT/CT+CC | CT/CC | CT/TT+CC | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Multivariate logistic regressiona | Exp(B) (95% CI) | P | Exp(B) (95% CI) | P | Exp(B) (95% CI) | P | Exp(B) (95% CI) | P | Exp(B) (95% CI) | P |
| Interventricular septum thickness (mm) |
1.739 (1.156–2.615) |
0.008 | 1.801 (1.141–2.843) |
0.012 | 1.876 (1.260–2.792) |
0.002 | 1.310 (0.876–1.960) |
0.188 | 0.886 (0.671–1.170) |
0.393 |
| Left ventricular posterior wall thickness (mm) |
2.016 (1.244–3.267) |
0.004 | 1.925 (1.145–3.236) |
0.013 | 2.070 (1.318–3.250) |
0.002 | 1.161 (0.698–1.931) |
0.565 | 0.776 (0.549–1.097) |
0.151 |
| Left ventricular end-diastolic diameter (mm) |
1.207 (1.070–1.361) |
0.002 | 1.053 (0.954–1.162) |
0.301 | 1.118 (1.022–1.222) |
0.015 | 0.909 (0.829–0.996) |
0.040 | 0.888 (0.821–0.961) |
0.003 |
| Right ventricle end-diastolic diameter (mm) |
0.938 (0.806–1.091) |
0.405 | 0.923 (0.766–1.112) |
0.399 | 0.927 (0.800–1.073) |
0.310 | 0.967 (0.844–1.108) |
0.630 | 1.006 (0.900–1.125) |
0.915 |
| Left atrium end-systolic diameter (mm) |
0.941 (0.823–1.076) |
0.373 | 0.899 (0.792–1.021) |
0.100 | 0.915 (0.817–1.025) |
0.125 | 0.975 (0.897–1.059) |
0.545 | 1.008 (0.936–1.086) |
0.832 |
| Right atrium end-systolic diameter (mm) |
0.913 (0.772–1.079) |
0.287 | 0.939 (0.780–1.129) |
0.502 | 0.927 (0.801–1.073) |
0.309 | 0.965 (0.855–1.090) |
0.570 | 1.000 (0.899–1.112) |
0.996 |
| Pulmonary artery diameter (mm) |
0.908 (0.702–1.175) |
0.464 | 1.104 (0.805–1.513) |
0.539 | 0.965 (0.775–1.202) |
0.753 | 1.153 (0.930–1.430) |
0.194 | 1.129 (0.938–1.359) |
0.198 |
| Aorta diameter (mm) |
0.892 (0.772–1.030) |
0.121 | 0.941 (0.791–1.118) |
0.488 | 0.907 (0.796–1.035) |
0.147 | 1.063 (0.943–1.198) |
0.318 | 1.085 (0.980–1.201) |
0.116 |
| Left ventricular ejection fraction (%) |
0.958 (0.886–1.036) |
0.284 | 1.044 (0.960–1.134) |
0.314 | 0.992 (0.928–1.060) |
0.812 | 1.050 (0.987–1.117) |
0.124 | 1.046 (0.989–1.105) |
0.114 |
a
With adjustment of age, sex, nationality, hypertension, fasting blood glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.