Table 2.
Comparison of laboratory test results among four groups.
| Parameters | All (n = 211) | A (n = 53) | B (n = 53) | C (n = 53) | D (n = 52) |
|---|---|---|---|---|---|
| Serum Lipids | |||||
| TC, mmol/L | 3.7 (3.3,4.2) | 4.6 (4.2,5) | 3.9 (3.7,4.1)* | 3.5 (3.3,3.6)*# | 2.9 (2.6,3.2)*#& |
| TG, mmol/L | 1.2 (1,1.7) | 1.5 (1.1,2) | 1.4 (1.1,1.7) | 1.1 (0.9,1.5)* | 1.1 (0.9,1.4)*# |
| HDL, mmol/L | 0.9 (0.7,1) | 0.9 (0.8,1.1) | 0.9 (0.8,1) | 0.9 (0.7,1.1) | 0.9 (0.7,1) |
| Lipoprotein a, mg/L | 124.0 (69,253.7) | 159 (99,296) | 127 (69,254) | 124 (68,191)* | 90.5 (63,145.5)*# |
| Arterial blood gas analysisa | |||||
| Arterial oxygen saturation, % | 94 (88.3,98) | 93 (79.5,96) | 95 (89.8,98.3) | 95.5 (89.8,98) | 93.5 (88.8,97) |
| Arterial partial pressure of oxygen, mmHg | 73 (53,94) | 71 (44,82) | 74.5 (61,110) | 84 (59,101) | 71 (54,92) |
| Lactic acid, mmol/L | 2.1 (1.6,2.9) | 2.2 (1.7,2.8) | 2.2 (1.6,3.6) | 2.2 (1.8,3.1) | 2.1 (1.4,2.4) |
| Blood routineb | |||||
| White blood cell count, × 109/L | 5.7 (4.4,8.3) | 5.8 (4.7,8.7) | 7 (5.2,8.4) | 5.5 (4.3,7) | 5.3 (4.1,7.9) |
| Neutrophil count, × 109/L | 4.2 (2.9,6.7) | 3.9 (3.1,6.9) | 5.5 (3,6.9) | 3.7 (2.6,5.5) | 4.1 (2.6,6.8) |
| Neutrophil % | 75 (62.9,85.8) | 72.2 (65.2,83.5) | 80.5 (66.1,89.3) | 74.4 (61.1,83) | 77.1 (64.7,89.6) |
| Lymphocyte count, × 109/L | 0.9 (0.6,1.3) | 1 (0.8,1.5) | 0.8 (0.5,1.3)* | 0.9 (0.8,1.4) | 0.7 (0.5,1.1)*& |
| Lymphocyte % | 16.7 (8.5,25.9) | 19.6 (9.6,25.5) | 12.9 (5.5,23.1) | 16.9 (11.1,28.9) | 16.2 (6.4,26.7) |
| Platelet count, × 109/L | 200 (154,263) | 240 (195,325) | 222 (176,285) | 185 (148,222)*# | 156.5 (120.3,204.8)*# |
| <125 | 27 (12.9%) | 1 (1.9%) | 5 (9.4%) | 7 (13.2%)* | 14 (28%)*# |
| >350 | 18 (8.6%) | 10 (18.9%) | 7 (13.2%) | 0 (0%)*# | 1 (2%)* |
| Red blood cell count, × 1010/L | 4.1 (3.8,4.5) | 4.1 (3.7,4.5) | 4.1 (4,4.4) | 4.2 (3.9,4.6) | 4 (3.7,4.3) |
| Liver function | |||||
| ALT,U/L | 25 (18,40) | 25 (18,59) | 25 (19,40) | 21 (16,37) | 29 (20.5,36) |
| AST,U/L | 30 (22,46.5) | 29 (22,45) | 29 (21,41) | 28 (20,45) | 39 (27.5,54.3)*#& |
| Total bilirubin, mol/L | 10.9 (8.4,15.5) | 12.6 (8.8,16.6) | 11.6 (9.7,18.4) | 9.7 (7.3,13.5)*# | 10.6 (8.4,15) |
| Total protein, g/L | 60.2 (56.8,64.5) | 62.2 (58.6,65.2) | 60.8 (57.2,64.4) | 59.4 (56.5,65.2) | 58.8 (56.3,62.6) |
| Kidney function | |||||
| Creatinine, μmol/L | 61 (50.5,76) | 56 (49,70) | 60 (50,73) | 62 (52,78) | 70.5 (51.8,84.3) |
| Blood urea nitrogen, nmol/L | 4.8 (3.7,6.9) | 4.1 (3.7,5.8) | 5.2 (3.6,7.2) | 5 (3.4,7) | 4.9 (3.9,7.6) |
| Uric acid, μmol/L | 240 (200.5,320) | 231 (199,293) | 243 (214,299) | 261 (219,338) | 236.5 (188.8,335.5) |
| EGFR, mL/min | 96.6 (89.1,106.8) | 96.9 (91.6,106.4) | 95.5 (88.9,106.9) | 99.1 (88.4,113.2) | 94.2 (80.1,101.9) |
| ≤ 90 | 56 (26.5%) | 9 (17%) | 15 (28.3%) | 14 (26.4%) | 18 (34.6%)* |
| Cardiac injury | |||||
| Creatine kinase, U/L | 67 (41.5,117) | 65 (44,94) | 56 (35,105) | 79 (48,119)# | 80 (52.5,243.8)# |
| >310 | 21 (10%) | 2 (3.8%) | 3 (5.7%) | 5 (9.4%) | 11 (21.2%)*# |
| Lactate dehydrogenase, U/Lc | 310 (230,426.3) | 305.5 (245.5,375.3) | 311 (227,451) | 292 (212,427) | 355.5 (247,453) |
| Myoglobin, μg/Ld | 46.9 (31.6,86.1) | 51.1 (33,74.3) | 47.2 (28.8,87) | 40.3 (33.3,69) | 57.8 (33.2,86.6) |
| Creatine kinase-myocardial band isoenzyme, ng/mle | 1 (0.7,2.1) | 1 (0.6,2.1) | 1 (0.7,2.3) | 1.1 (0.7,1.6) | 1.2 (0.6,2.5) |
| Hypersensitive troponin I, ng/mLf | 0.006 (0.006,0.023) | 0.006 (0.006,0.013) | 0.006 (0.006,0.012) | 0.006 (0.006,0.029) | 0.009 (0.006,0.049) |
| Non-specific inflammation index | |||||
| C-reactive protein, mg/Lg | 47.5 (10.9,92.3) | 27.7 (6.6,62.9) | 65.5 (28.3,96.9)* | 51 (5.7,89.5) | 58.1 (23.5,104.1)* |
| >10, | 139 (75.5%) | 30 (63.8%) | 42 (85.7%)* | 32 (72.7%) | 35 (79.5%) |
| High-sensitivity C-reactive protein, mg/Lg | 5 (5,5) | 5 (5,5) | 5 (5,5) | 5 (5,5) | 5 (5,5) |
| Procalcitonin, ng/mLh | 0.08 (0,0.17) | 0.056 (0.035,0.102) | 0.081 (0.047,0.17)* | 0.039 (0.05,0.17) | 0.049 (0.11,0.29)* |
| Coagulation functioni | |||||
| D-dimer, μmol/L | 0.8 (0.5,2.2) | 0.7 (0.5,1.8) | 1 (0.5,2.6) | 0.6 (0.3,1.8) | 0.8 (0.4,2.2) |
| Prothrombin time activity, % | 81.2 (74.4,88) | 83.2 (74.9,92.5) | 80 (74.3,88.8) | 81.4 (74.6,84.9) | 78.8 (71.5,87.6) |
| Activated partial thromboplastin time, s | 28.5 (26.1,31) | 27.3 (24.9,28.7) | 27.7 (26.3,30.7) | 29.3 (27.3,32.7)* | 29.8 (28.1,33.6)*# |
| Cellular immunityj | |||||
| CD16+56, % | 8 (8,21.8) | 14.2 (8.8,21.6) | 12.5 (6.5,22.1) | 14 (9.7,18.5) | 14.6 (8.7,22.5) |
| CD16+56 counts, No./μl | 69 (69,179.8) | 148 (78,190) | 88 (59.5,124.5) | 100 (74,223) | 103 (64,153.5) |
| CD19, % | 12.3 (12.3,21.8) | 17.3 (13.5,21.8) | 16.9 (12.2,21.4) | 16.4 (12.8,20) | 14.9 (10.7,23.5) |
| CD19 counts, No./μl | 84.5 (84.5,202.5) | 148 (109.5,245) | 127 (68.5,200.5) | 141 (103,190) | 103 (74.5,144)*& |
| CD3, % | 55 (55,73.3) | 62.9 (55.3,69.9) | 66 (51.6,74.6) | 68.1 (58.9,75.2) | 62.3 (53.8,73.1) |
| CD3 counts No./μl | 311 (311,822.8) | 551 (411.5,835) | 466 (270,961.5) | 582 (436,972) | 467 (258.5,694.5) |
| CD4, % | 32.3 (32.3,46.1) | 40.1 (33.9,46.2) | 40.6 (31.5,48.2) | 41 (32.4,46) | 38 (31,44.3) |
| CD4 counts, No./μl | 193 (193,510.8) | 380 (304,520.5) | 275 (151,581.5)* | 346 (207,576) | 266 (162,399)* |
| CD8, % | 15.4 (15.4,29) | 18.7 (14.9,26.5) | 20.6 (15,27.8) | 25.1 (16,30.3) | 20 (15.6,31.3) |
| CD8 counts, No./μL | 95.5 (95.5,287.3) | 173 (121,263) | 176 (75,296.5) | 215 (126,316) | 123 (87,272.5) |
| CD4/CD8 | 1.2 (1.2,2.8) | 2.1 (1.4,3) | 1.9 (1.2,3.2) | 1.6 (1.2,2.5) | 1.7 (1.2,2.5) |
TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; EGFR, estimated glomerular filtration rate; Data are Median (IQR) or n (%). The total number of patients with available data: a: n(A) = 26, n(B) = 24, n(C) = 28, n(D) = 36; b: n(A) = 53, n(B) = 53, n(C) = 53, n(D) = 50; c: n(A) = 52, n(B) = 53, n(C) = 53, n(D) = 52; d: n(A) = 47, n(B) = 49, n(C) = 45, n(D) = 39; e: n(A) = 47, n(B) = 49, n(C) = 45, n(D) = 40; f: n(A) = 48, n(B) = 49, n(C) = 46, n(D) = 40; g: n(A) = 47, n(B) = 49, n(C) = 44, n(D) = 44; h: n(A) = 49, n(B) = 49, n(C) = 49, n(D) = 47; i: n(A) = 51, n(B) = 48, n(C) = 48, n(D) = 46; j: n(A) = 43, n(B) = 43, n(C) = 41, n(D) = 43;
*
P < 0.05 vs. group A;
#
P < 0.05 vs. group B;
&
P < 0.05 vs. group C. Different laboratory indicators have different data volumes, different alphabets are used to show the number of patients in each group of this indicator.