Table 2.
Individually pair matched case–control analysis for AS from training set.
| All | Non-AS | AS | pb | |
|---|---|---|---|---|
| Individually pair matched case–control seta | ||||
| n | 348 | 232 | 116 | |
| Age | 62.71 (14.03) | 61.51 (10.87) | 65.12 (13.43) | 0.007 |
| Age group n (%)c | 1 | |||
| Young | 30 (8.6) | 20 (8.6) | 10 (8.6) | |
| Middle-aged | 138 (39.7) | 92 (39.7) | 46 (39.7) | |
| Elderly | 180 (51.7) | 120 (51.7) | 60 (51.7) | |
| Sex, men, n (%) | 276 (79.3) | 184 (79.3) | 92 (79.3) | 1 |
| BMI (kg/m2) | 24.83 (3.25) | 24.89 (3.20) | 24.72 (3.37) | 0.637 |
| BMI group, n (%)d | 1 | |||
| Low weight | 3 (0.9) | 2 (0.9) | 1 (0.9) | |
| Normal | 144 (41.4) | 96 (41.4) | 48 (41.4) | |
| Obesity | 51 (14.7) | 34 (14.7) | 17 (14.7) | |
| Over weight | 150 (43.1) | 100 (43.1) | 50 (43.1) | |
| Hyperlipidemia, n (%)e | 72 (20.7) | 48 (20.7) | 24 (20.7) | 1 |
| CAVI (m/s) | 8.55 (1.48) | 7.79 (0.90) | 10.06 (1.23) | <0.001 |
| Smoke, yes, n (%) | 134 (37.9) | 88 (37.9) | 46 (39.7) | 0.846 |
| Alcohol, yes, n (%) | 115 (35.3) | 82 (35.3) | 33 (28.4) | 0.243 |
| LY (G/L) | 1.69 [1.36, 2.06] | 1.65 [1.40, 2.05] | 1.71 [1.30, 2.10] | 0.883 |
| NE (G/L) | 3.20 [2.57, 4.05] | 3.04 [2.51, 3.76] | 3.65 [2.67, 4.70] | 0.001 |
| MO (G/L) | 0.38 [0.29, 0.50] | 0.37 [0.27, 0.46] | 0.42 [0.33, 0.57] | <0.001 |
| PLT (G/L) | 197.00 [162.75, 231.00] | 191.00 [161.00, 226.25] | 204.50 [166.00, 234.00] | 0.057 |
| NLR | 1.84 [1.43, 2.57] | 1.77 [1.39, 2.37] | 1.95 [1.62, 2.91] | 0.004 |
| MLR | 0.22 [0.17, 0.30] | 0.21 [0.16, 0.27] | 0.25 [0.19, 0.33] | <0.001 |
| PLR | 115.92 [91.61, 139.79] | 115.31 [91.12, 136.73] | 120.25 [99.63, 149.22] | 0.167 |
| UA (μmol/L) | 361.20 [310.175, 425.200] | 357.85 [308.08, 425.20] | 368.30 [320.48, 425.68] | 0.342 |
| FBG (μmol/L) | 5.03 [4.62, 5.78] | 5.00 [4.61, 5.60] | 5.16 [4.65, 6.12] | 0.133 |
| TGs (mmol/L) | 1.33 [0.96, 1.95] | 1.34 [0.93, 1.96] | 1.24 [1.02, 1.94] | 0.839 |
| CHOL (mmol/L) | 4.08 [3.40, 4.83] | 4.08 [3.38, 4.91] | 4.06 [3.49, 4.79] | 0.843 |
| LDL-C (mmol/L) | 2.40 [1.87, 3.06] | 2.38 [1.87, 3.05] | 2.41 [1.92, 3.06] | 0.841 |
| HTN, yes, n (%) | 234 (67.2) | 156 (67.2) | 78 (67.2) | 1 |
| DM, yes, n (%) | 69 (19.8) | 46 (19.8) | 23 (19.8) | 1 |
Values are represented as mean (SD), medians [interquartile range (IQR)], or n (%).
The data set derived from the training set with matching according to the ratio of the cases (AS) and controls (non-AS) as 1:2. The matching elements include sex, the age group, the BMI group, hyperlipidemia, HTN, and DM.
Between the groups, the t test and Mann–Whitney U test were used to continuity data with and without normal distribution, respectively; the χ2 test was used for categorical data.
The age group, all training samples are divided into three equal parts according to age: young (age <51 years), middle-aged (51 ≤ age <62 years) and elderly (age ≥62 years).
The BMI group, all training samples are divided into low weight (BMI ≤ 18.5 kg/m2), the normal (18.5 kg/m2 < BMI ≤ 23.9 kg/m2), overweight (23.9 kg/m2 < BMI ≤ 27.9 kg/m2), and obesity (BMI > 27.9 kg/m2).
Hyperlipidemia (20) (TGs ≥ 2.3 mmol/L or CHOL ≥ 6.2 mmol/L or LDL-C ≥ 4.1 mmol/L) and the normal (TGs <2.3 mmol/L and CHOL <6.2 mmol/L and LDL-C <4.1 mmol/L).