. 2021 Jul 5;31(7):426–450. doi: 10.2188/jea.JE20200416

Table 3. Results of joinpoint regression analysis on the trends in all-cancer mortality: national data (1958–2018).

Age	Sex	Cancer site	ICD-10	Number of joinpoints	Line segment		Annual % change	95% confidence interval

					Start	End		Lower	Upper
All ages	Male and female	All cancers	C00–C97	4	1958	1966	0.4	0.1	0.8	^*
					1966	1993	−0.2	−0.2	−0.1	^*
					1993	1997	0.6	−0.3	1.5
					1997	2015	−1.4	−1.4	−1.3	^*
					2015	2018	−2.2	−3.0	−1.4	^*

		All cancers excluding stomach	C00–C97 (excluding C16)	5	1958	1975	1.1	1.0	1.2	^*
					1975	1984	1.7	1.5	1.9	^*
					1984	1993	0.7	0.5	0.9	^*
					1993	1997	1.4	0.6	2.2	^*
					1997	2016	−1.0	−1.1	−1.0	^*
					2016	2018	−2.3	−3.8	−0.9	^*

		All cancers excluding stomach and liver	C00–C97 (excluding C16 and C22)	4	1958	1984	1.5	1.4	1.5	^*
					1984	1992	0.5	0.2	0.7	^*
					1992	1996	1.6	0.7	2.5	^*
					1996	2015	−0.6	−0.6	−0.5	^*
					2015	2018	−1.4	−2.2	−0.6	^*

	Male	All cancers	C00–C97	4	1958	1988	0.5	0.5	0.6	^*
					1988	1992	−0.5	−1.7	0.7
					1992	1996	1.5	0.4	2.7	^*
					1996	2013	−1.6	−1.6	−1.5	^*
					2013	2018	−2.5	−2.9	−2.0	^*

		All cancers excluding stomach	C00–C97 (excluding C16)	4	1958	1975	2.0	1.8	2.2	^*
					1975	1983	2.8	2.3	3.3	^*
					1983	1997	1.3	1.2	1.4	^*
					1997	2013	−1.3	−1.3	−1.2	^*
					2013	2018	−2.1	−2.5	−1.6	^*

		All cancers excluding stomach and liver	C00–C97 (excluding C16 and C22)	4	1958	1963	3.6	2.2	5.0	^*
					1963	1982	2.4	2.3	2.5	^*
					1982	1997	1.3	1.2	1.5	^*
					1997	2014	−0.8	−0.9	−0.7	^*
					2014	2018	−1.9	−2.5	−1.2	^*

		All cancers excluding prostate	C00–C97 (excluding C61)	4	1958	1987	0.5	0.4	0.5	^*
					1987	1992	−0.4	−1.1	0.4
					1992	1996	1.2	0.1	2.4	^*
					1996	2013	−1.6	−1.7	−1.5	^*
					2013	2018	−2.5	−2.9	−2.0	^*

	Female	All cancers	C00–C97	4	1958	1968	−0.1	−0.3	0.1
					1968	1993	−0.8	−0.9	−0.8	^*
					1993	1997	0.5	−0.4	1.4
					1997	2003	−1.4	−1.8	−1.0	^*
					2003	2018	−1.0	−1.1	−0.9	^*

		All cancers excluding stomach	C00–C97 (excluding C16)	4	1958	1976	0.1	0.0	0.2
					1976	1980	1.0	−0.2	2.2
					1980	1993	0.2	0.0	0.3	^*
					1993	1997	0.9	0.0	1.9	^*
					1997	2018	−0.7	−0.8	−0.7	^*

		All cancers excluding stomach and liver	C00–C97 (excluding C16 and C22)	5	1958	1976	0.4	0.3	0.5	^*
					1976	1981	0.9	0.2	1.7	^*
					1981	1993	0.1	−0.1	0.2
					1993	1997	1.0	0.1	1.9	^*
					1997	2003	−0.8	−1.2	−0.4	^*
					2003	2018	−0.3	−0.4	−0.2	^*

		All cancers excluding breast	C00–C97 (excluding C50)	5	1958	1968	−0.2	−0.4	0.0
					1968	1993	−1.0	−1.0	−1.0	^*
1993					1997	0.1	−0.8	0.9
1997					2007	−1.6	−1.7	−1.4	^*
2007					2014	−1.0	−1.3	−0.7	^*
2014					2018	−1.7	−2.3	−1.1	^*

ICD-10, International Classification of Diseases, 10th revision.

^*Annual % change was statistically significantly different from zero (P < 0.05).