. 2021 Jul 5;31(7):426–450. doi: 10.2188/jea.JE20200416

Table 4A. Results of joinpoint regression analysis on the trends in site-specific cancer mortality: national data (1958–2018); Male.

Cancer site		ICD-10	Number of joinpoints	Line segment		Annual % change	95% confidence interval

				Start	End		Lower	Upper
Major
	Stomach	C16	5	1958	1969	−0.5	−0.7	−0.3	^*
				1969	1981	−2.6	−2.9	−2.4	^*
				1981	1992	−3.3	−3.6	−3.1	^*
				1992	1996	−1.4	−2.9	0.2
				1996	2012	−3.2	−3.3	−3.1	^*
				2012	2018	−4.6	−5.1	−4.0	^*
	Colon	C18	4	1958	1985	4.7	4.6	4.9	^*
				1985	1996	3.0	2.7	3.2	^*
				1996	2009	−1.3	−1.4	−1.1	^*
				2009	2015	0.1	−0.4	0.6
				2015	2018	−1.3	−2.4	−0.2	^*
	Rectum	C19–C20	2	1958	1975	2.2	1.8	2.5	^*
				1975	1998	0.5	0.3	0.6	^*
				1998	2018	−1.0	−1.1	−0.9	^*
	Colon/rectum	C18–C20	3	1958	1980	3.1	2.9	3.3	^*
				1980	1996	2.1	1.9	2.2	^*
				1996	2009	−1.1	−1.3	−1.0	^*
				2009	2018	−0.5	−0.7	−0.3	^*
	Liver	C22	5	1958	1974	−0.6	−0.9	−0.3	^*
				1974	1986	4.2	3.9	4.6	^*
				1986	1996	1.0	0.6	1.3	^*
				1996	2002	−2.3	−3.1	−1.6	^*
				2002	2010	−4.2	−4.7	−3.8	^*
				2010	2018	−5.5	−5.9	−5.1	^*
	Pancreas	C25	3	1958	1968	7.3	6.4	8.2	^*
				1968	1987	3.1	2.9	3.3	^*
				1987	2002	0.1	−0.1	0.3
				2002	2018	0.5	0.4	0.6	^*
	Lung, trachea	C33–C34	5	1958	1963	7.5	5.8	9.2	^*
				1963	1981	4.6	4.4	4.8	^*
				1981	1989	2.2	1.9	2.6	^*
				1989	1996	1.0	0.6	1.4	^*
				1996	2012	−0.9	−1.0	−0.8	^*
				2012	2018	−2.5	−2.8	−2.2	^*
	Prostate	C61	3	1958	1993	3.3	3.1	3.4	^*
				1993	1997	5.7	2.8	8.7	^*
				1997	2005	0.1	−0.6	0.7
				2005	2018	−1.7	−1.9	−1.5	^*
Sub-major
	Esophagus	C15	5	1958	1971	1.4	1.0	1.7	^*
				1971	1977	−2.1	−3.3	−0.8	^*
				1977	1994	−0.1	−0.3	0.1
				1994	1998	2.0	0.1	4.0	^*
				1998	2008	−1.1	−1.4	−0.7	^*
				2008	2018	−2.9	−3.2	−2.6	^*
	Urinary bladder	C67	3	1958	1980	1.2	0.9	1.5	^*
				1980	1988	−1.6	−2.9	−0.3	^*
				1988	1999	1.2	0.5	1.8	^*
				1999	2018	−0.4	−0.6	−0.3	^*
	Kidney and other urinary organs (except bladder)	C64–C66 C68	4	1958	1977	4.1	3.7	4.6	^*
				1977	1984	6.0	4.5	7.6	^*
				1984	1996	2.3	1.9	2.7	^*
				1996	2016	0.9	0.7	1.0	^*
				2016	2018	−4.7	−8.4	−0.8	^*
	Thyroid	C73	2	1958	1966	7.4	3.3	11.7	^*
				1966	1997	0.6	0.2	0.9	^*
				1997	2018	−1.0	−1.3	−0.6	^*
	Malignant lymphoma	C81–C85 C96	4	1958	1967	4.0	3.0	4.9	^*
				1967	1980	2.4	2.0	2.9	^*
				1980	2001	0.7	0.6	0.9	^*
				2001	2005	−2.6	−4.8	−0.4	^*
				2005	2018	−0.2	−0.4	0.0
Others
	Oral cavity and pharynx	C00–C14	3	1958	1992	1.8	1.7	2.0	^*
				1992	1996	7.6	3.8	11.5	^*
				1996	2008	0.5	0.1	0.9	^*
				2008	2018	−0.7	−1.1	−0.3	^*
	Gallbladder and bile ducts	C23–C24	4	1958	1965	10.1	8.3	12.0	^*
				1965	1987	4.4	4.2	4.6	^*
				1987	1995	0.4	−0.1	1.0
				1995	2012	−1.5	−1.7	−1.4	^*
				2012	2018	−2.3	−2.9	−1.8	^*
	Larynx	C32	3	1958	1972	0.3	−0.2	0.8
				1972	1991	−3.2	−3.5	−2.9	^*
				1991	1997	0.7	−1.3	2.8
				1997	2018	−3.9	−4.2	−3.7	^*
	Skin	C43–C44	2	1958	1974	−1.3	−2.0	−0.5	^*
				1974	1987	−4.8	−5.8	−3.7	^*
				1987	2018	0.0	−0.3	0.2
	Brain, nervous system	C70–C72	4	1958	1970	1.3	−0.3	2.9
				1970	1980	5.7	4.0	7.5	^*
				1980	1996	1.6	1.1	2.2	^*
				1996	2007	−0.3	−1.2	0.6
				2007	2018	3.3	2.6	4.1	^*
	Multiple myeloma	C88–C90	3	1958	1968	12.8	9.8	15.8	^*
				1968	1980	6.3	5.0	7.7	^*
				1980	2000	1.7	1.4	2.1	^*
				2000	2018	−2.0	−2.3	−1.8	^*
	Leukemia	C91–C95	4	1958	1976	2.3	2.1	2.6	^*
				1976	1987	1.4	1.0	1.9	^*
				1987	1991	−1.9	−4.6	0.8
				1991	1999	−0.2	−0.9	0.5
				1999	2018	−1.1	−1.2	−0.9	^*

ICD-10, International Classification of Diseases, 10th revision.

^*Annual % change was statistically significantly different from zero (P < 0.05).