Table 4B. Results of joinpoint regression analysis on the trends in site-specific cancer mortality: national data (1958–2018); Female.

Cancer site		ICD-10	Number of joinpoints	Line segment		Annual % change	95% confidence interval
				Start	End		Lower	Upper
Major
	Stomach	C16	4	1958	1970	−0.8	−1.0	−0.6	*
				1970	1979	−3.2	−3.5	−2.9	*
				1979	1991	−4.4	−4.6	−4.2	*
				1991	1999	−3.3	−3.8	−2.9	*
				1999	2018	−3.9	−4.0	−3.8	*
	Colon	C18	5	1958	1982	3.4	3.3	3.5	*
				1982	1993	2.3	2.0	2.6	*
				1993	2004	−0.4	−0.7	−0.2	*
				2004	2008	−2.3	−3.7	−0.9	*
				2008	2014	0.4	−0.2	1.0
				2014	2018	−0.9	−1.8	0.0
	Rectum	C19–C20	1	1958	1974	1.3	1.0	1.6	*
				1974	2018	−1.3	−1.3	−1.2	*
	Colon/rectum	C18–C20	5	1958	1974	2.3	2.1	2.6	*
				1974	1992	1.1	1.0	1.3	*
				1992	2004	−0.5	−0.7	−0.3	*
				2004	2009	−2.1	−3.0	−1.2	*
				2009	2014	0.4	−0.5	1.3
				2014	2018	−1.1	−2.0	−0.2	*
	Liver	C22	4	1958	1975	−2.4	−2.6	−2.1	*
				1975	1989	0.2	−0.1	0.5
				1989	1999	1.4	0.9	1.8	*
				1999	2008	−2.9	−3.4	−2.5	*
				2008	2018	−5.7	−6.1	−5.4	*
	Pancreas	C25	5	1958	1967	6.4	5.5	7.4	*
				1967	1988	2.8	2.7	3.0	*
				1988	1994	−0.4	−1.3	0.5
				1994	2006	0.6	0.4	0.8	*
				2006	2011	2.1	1.1	3.1	*
				2011	2018	0.7	0.4	1.1	*
	Lung, trachea	C33–C34	5	1958	1963	6.5	4.2	8.8	*
				1963	1984	3.1	2.9	3.3	*
				1984	1998	0.9	0.7	1.1	*
				1998	2003	−1.8	−2.8	−0.7	*
				2003	2014	−0.2	−0.4	0.1
				2014	2018	−2.3	−3.3	−1.4	*
	Breast	C50	5	1958	1964	−0.5	−2.1	1.1
				1964	1978	2.3	1.9	2.8	*
				1978	1990	1.5	1.1	1.9	*
				1990	1997	3.2	2.4	4.0	*
				1997	2006	1.4	0.9	1.8	*
				2006	2018	0.4	0.2	0.6	*
	Uterus	C53–C55	5	1958	1969	−3.1	−3.3	−2.9	*
				1969	1979	−4.4	−4.8	−4.1	*
				1979	1987	−5.4	−6.0	−4.9	*
				1987	1993	−3.1	−4.1	−2.1	*
				1993	2007	−0.3	−0.6	−0.1	*
				2007	2018	1.0	0.7	1.3	*
	Cervix uteri	C53	4	1958	1965	−1.9	−3.3	−0.5	*
				1965	1973	−5.1	−6.5	−3.8	*
				1973	1978	1.0	−2.4	4.6
				1978	1989	−2.4	−3.2	−1.6	*
				1989	2018	0.4	0.3	0.6	*
	Corpus uteri	C54	3	1958	1966	−6.2	−8.1	−4.3	*
				1966	1972	−14.3	−19.1	−9.3	*
				1972	1996	4.3	3.8	4.7	*
				1996	2018	3.0	2.7	3.3	*
Sub-major
	Esophagus	C15	2	1958	1969	−0.1	−0.7	0.5
				1969	1989	−3.9	−4.1	−3.6	*
				1989	2018	−0.7	−0.9	−0.6	*
	Gallbladder and bile ducts	C23–C24	4	1958	1963	12.0	9.0	15.1	*
				1963	1972	6.1	5.1	7.0	*
				1972	1985	4.1	3.7	4.4	*
				1985	1992	0.1	−0.5	0.8
				1992	2018	−3.1	−3.1	−3.0	*
	Ovary	C56	4	1958	1981	3.9	3.7	4.1	*
				1981	1996	1.3	1.1	1.6	*
				1996	2000	−2.6	−5.1	0.0	*
				2000	2011	−0.2	−0.6	0.2
				2011	2018	−1.1	−1.8	−0.4	*
	Urinary bladder	C67	2	1958	1969	1.6	0.6	2.6	*
				1969	1990	−1.7	−2.0	−1.4	*
				1990	2018	−0.2	−0.3	0.0	*
	Kidney and other urinary organs (except bladder)	C64–C66 C68	3	1958	1976	1.5	0.9	2.1	*
				1976	1986	3.8	2.6	5.1	*
				1986	2006	1.5	1.2	1.7	*
				2006	2018	0.0	−0.4	0.4
	Thyroid	C73	2	1958	1977	1.9	1.5	2.4	*
				1977	2003	−1.0	−1.2	−0.8	*
				2003	2018	−1.8	−2.1	−1.4	*
	Malignant lymphoma	C81–C85 C96	3	1958	1981	2.5	2.3	2.7	*
				1981	2001	0.9	0.7	1.1	*
				2001	2006	−2.2	−3.8	−0.5	*
				2006	2018	0.0	−0.3	0.3
Others
	Oral cavity and pharynx	C00–C14	3	1958	1979	0.6	0.2	1.1	*
				1979	1991	−0.8	−1.7	0.0
				1991	1998	5.2	3.3	7.1	*
				1998	2018	−0.5	−0.8	−0.3	*
	Larynx	C32	2	1958	1976	−4.3	−5.0	−3.5	*
				1976	1986	−9.0	−11.3	−6.6	*
				1986	2018	−3.5	−4.0	−3.0	*
	Skin	C43–C44	3	1958	1973	−1.8	−2.8	−0.8	*
				1973	1988	−5.1	−6.1	−4.1	*
				1988	2012	0.8	0.3	1.3	*
				2012	2018	−2.7	−5.9	0.7
	Brain, nervous system	C70–C72	4	1958	1971	1.8	−0.1	3.7
				1971	1978	7.3	2.8	12.1	*
				1978	1998	1.5	1.0	2.1	*
				1998	2007	−0.6	−2.4	1.3
				2007	2018	3.2	2.1	4.3	*
	Multiple myeloma	C88–C90	4	1958	1968	14.8	11.9	17.9	*
				1968	1983	5.6	4.8	6.4	*
				1983	1997	1.5	1.0	1.9	*
				1997	2005	−0.2	−1.2	0.9
				2005	2018	−2.6	−3.0	−2.2	*
	Leukemia	C91–C95	2	1958	1967	2.9	2.1	3.8	*
				1967	1987	0.6	0.4	0.8	*
				1987	2018	−1.5	−1.6	−1.4	*

ICD-10, International Classification of Diseases, 10th revision.

^*Annual % change was statistically significantly different from zero (P < 0.05).