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. 2021 Jun 8;12(6):589. doi: 10.1038/s41419-021-03878-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A UMAP plot showing 11 NK/T cell clusters in liver transplantation, colored according to different clusters (left panel). Dendrogram of 11 clusters by the hierarchical clustering analysis based on their normalized mean expression values (right panel). B Violin plots showing the normalized expression of marker genes (y-axis) for NK/T cell clusters (x-axis). C Gene Ontology enrichment analysis results of NK/T cell clusters. Only the top 20 most significant GO terms (p value < 0.05) are shown in rows. D GSVA showing the pathways (PID gene sets) with significantly different activation in different samples of NK/T cell clusters. Different colors represent different activation scores. E Cell–cell interaction analysis between mononuclear phagocyte clusters and different NK/T cell clusters in PR samples. Ligand–receptor pairs labeled in y-axis. The size of the circle represents the level of p value, and different colors represent different means values. Ligands come from mononuclear phagocyte clusters, and receptors come from NK/T cell clusters.