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. 2021 Jun 8;11:353. doi: 10.1038/s41398-021-01468-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–c Detection of NLRP3 inflammasome in the hippocampus of CUMS mice. Western blot analysis of (a) NLRP3 (n = 6–8/group), (b) cleaved caspase-1 (n = 6–8/group), and (c) Il-1β (n = 6–8/group). All data are expressed as the mean ± SD. *p < 0.05, compared with control group; ^##p < 0.01, compared with vehicle group. d–h In order to detect whether or not NLRP3 inflammasome plays a key role in CUMS-induced depression, NLRP3 KO mice were used in this experiment. d The experimental paradigm and the experimental group. e The time spent immobile in the FST (n = 10/group). f Rearing numbers in the OFT (n = 10/group). g Total distance traveled in the OFT (n = 10/group). h Open-arm time proportion in the EPM test (n = 10/group). All data are expressed as the mean ± SD. **p < 0.01, ***p < 0.001, compared with wild-type group.