Table 1.
Metabolite concentrations in villi from individuals with RSA or normal controls.
| Metabolites (μmol/g) | Normal (n = 30) | RSA (n = 30) | P value | Adjusted P value |
|---|---|---|---|---|
| Glucose | 3.166 ± 0.893 | 3.257 ± 0.767 | 0.676 | 0.947 |
| Pyruvate | 0.306 ± 0.085 | 0.279 ± 0.09 | 0.251 | 0.828 |
| Lactate | 3.367 ± 1.221 | 2.881 ± 0.921 | 0.087 | 0.828 |
| Citrate | 0.303 ± 0.097 | 0.277 ± 0.085 | 0.282 | 0.828 |
| Succinate | 0.589 ± 0.121 | 0.429 ± 0.109 | 1.48 × 10−6 | 5.18 × 10−5 |
| Fumarate | 0.146 ± 0.05 | 0.174 ± 0.053 | 0.037 | 0.653 |
| Phenylalanine | 0.226 ± 0.048 | 0.212 ± 0.049 | 0.265 | 0.828 |
| Tyrosine | 0.209 ± 0.044 | 0.208 ± 0.061 | 0.910 | 0.992 |
| Aspartate | 1.598 ± 0.419 | 1.502 ± 0.484 | 0.413 | 0.828 |
| Glutamate | 2.088 ± 0.656 | 1.874 ± 0.684 | 0.221 | 0.828 |
| Glutamine | 2.821 ± 0.722 | 2.659 ± 0.731 | 0.391 | 0.828 |
| Glycine | 1.428 ± 0.589 | 1.367 ± 0.478 | 0.664 | 0.947 |
| Valine | 0.509 ± 0.121 | 0.509 ± 0.145 | 0.992 | 0.992 |
| Isoleucine | 0.273 ± 0.071 | 0.295 ± 0.107 | 0.370 | 0.828 |
| Leucine | 0.507 ± 0.113 | 0.516 ± 0.142 | 0.792 | 0.990 |
| Histidine | 0.182 ± 0.108 | 0.168 ± 0.098 | 0.594 | 0.945 |
| Alanine | 1.291 ± 0.298 | 1.223 ± 0.324 | 0.402 | 0.828 |
| Acetate | 0.294 ± 0.053 | 0.307 ± 0.072 | 0.426 | 0.828 |
| Formate | 0.362 ± 0.145 | 0.415 ± 0.214 | 0.264 | 0.828 |
| Inosine | 0.332 ± 0.192 | 0.315 ± 0.173 | 0.722 | 0.973 |
| Creatine | 1.062 ± 0.59 | 1.023 ± 0.503 | 0.784 | 0.990 |
| Hypoxanthine | 0.683 ± 0.233 | 0.63 ± 0.236 | 0.392 | 0.828 |
| Carnosine | 0.019 ± 0.012 | 0.019 ± 0.011 | 0.983 | 0.992 |
| Uridine | 0.338 ± 0.16 | 0.342 ± 0.17 | 0.932 | 0.992 |
| Taurine | 4.351 ± 2.288 | 3.778 ± 1.605 | 0.266 | 0.828 |
| 3-hydroxybutytrate | 0.366 ± 0.304 | 0.371 ± 0.317 | 0.946 | 0.992 |
| Nicotinamide | 0.113 ± 0.071 | 0.11 ± 0.061 | 0.857 | 0.992 |
| NAD | 0.024 ± 0.011 | 0.021 ± 0.012 | 0.317 | 0.828 |
| AMP | 0.009 ± 0.008 | 0.009 ± 0.008 | 0.935 | 0.992 |
| ADP | 0.017 ± 0.011 | 0.016 ± 0.01 | 0.594 | 0.945 |
| Uracil | 0.25 ± 0.056 | 0.235 ± 0.068 | 0.355 | 0.828 |
NAD nicotinamide adenine dinucleotide, AMP adenosine monophosphate, ADP adenosine diphosphate.
Data presented are given in μmol/g (mean ± SD). P values were derived from unpaired two-sample t test (two groups have the same SD) or unpaired two-sample t test with Welch’s correction (two groups do not have the equal SD) and then corrected by using the Benjamini & Hochberg method for multiple sampling (adjusted P value). Source data are provided as a Source Data file.