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. 2020 Nov 21;13:28. doi: 10.1007/s40820-020-00540-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Gold nanocages (GNCs) modification of BCP according to the immune response characteristics of macrophages and DCs and controlled release of IL-4 at the early stage implantation and DXMS at the late stage facilitate macrophage M2 polarization and inhibition of DC maturation to promote materials-mediated new bone formation