Table 2.

Multivariate analysis of predictors of DFS and OS in all NSCLC (A) and in PD-L1 negative NSCLC (B) using the median of CD8⁺ TILs as the threshold.

Variables	DFS			OS
	HR	95% CI	P value	HR	95% CI	P value
A
Sex
Male	1			1
Female	0.73	0.47-1.12	0.15	0.62	0.39-1.00	0.05
Age (years)
≤70	1			1
>70	0.94	0.62-1.42	0.78	1.08	0.69-1.07	0.71
Histology
Adenocarcinoma	1			1
Others	0.86	0.56-1.31	0.49	0.86	0.55-1.34	0.51
Surgery
Wedge/Lobectomy	1			1
Pneumonectomy	0.57	0.25-1.27	0.17	0.76	0.34-1.69	0.50
AdJuvant Treatment
No	1			1
Yes	1.00	0.58-1.73	0.97	1.14	0.64-2.01	0.65
TNM Stage
II - IV	1			1
I	0.27	0.17-0.43	0.00	0.31	0.19-0.50	0.00
CD8
<575/mm²	1			1
≥575/mm²	0.49	0.33-0.73	0.00	0.57	0.38-0.87	0.00
B
Sex
Male	1			1
Female	0.64	0.39-1.06	0.08	0.57	0.33-099	0.04
Age (years)
≤70	1			1
>70	1.07	0.65-1.76	0.76	1.24	0.73-2.11	0.42
Histology
Adenocarcinoma	1			1
Others	0.85	0.48-1.50	0.59	0.67	0.36-1.24	0.21
Surgery
Wedge/Lobectomy	1			1
Pneumonectomy	0.36	0.10-1.23	0.10	0.63	0.18-2.14	0.46
AdJuvant Treatment
No	1			1
Yes	1.01	0.51-1.96	0.97	1.08	0.53-2.18	0.82
TNM Stage
II - IV	1			1
I	0.25	0.14-0.44	0.00	0.30	0.17-0.53	0.00
CD8
<575/mm²	1			1
≥575/mm²	0.43	0.25-0.73	0.00	0.49	0.28-0.83	0.00