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. 2021 May 26;12:680973. doi: 10.3389/fimmu.2021.680973

Table 3.

Multivariate analysis of predictors of DFS and OS in PD-L1 negative NSCLC using the 25th percentile of CD8+ TILs (A) and in PD-L1 positive NSCLC using the 75th percentile of CD8+ TILs as threshold (B).

Variables DFS OS
HR 95% CI P value HR 95% CI P value
A
Sex
 Male 1 1
 Female 0.62 0.38-1.02 0.06 0.57 0.33-0.98 0.04
Age (years)
≤70 1 1
>70 1.20 0.74-1.97 0.45 1.25 0.74-2.12 0.40
Histology
 Adenocarcinoma 1 1
 Others 0.95 0.55-1.66 0.87 0.70 0.38-1.28 0.24
Surgery
 Wedge/Lobectomy 1 1
 Pneumonectomy 0.36 0.11-1.20 0.09 0.64 0.19-2.16 0.48
AdJuvant Treatment
 No 1 1
 Yes 1.04 0.54-1.20 0.91 1.12 0.56-2.23 0.74
TNM Stage
 II - IV 1 1
 I 0.28 0.16-0.49 0.00 0.31 0.17-0.55 0.00
CD8
 <300/mm² 1 1
 ≥300/mm² 0.48 0.30-0.77 0.00 0.50 0.31-0.82 0.00
B
Sex
 Male 1 1
 Female 0.91 0.38-2.21 0.84 0.66 0.24-1.83 0.43
Age (years)
 ≤70 1 1
 >70 0.54 0.22-1.30 0.17 0.81 0.33-2.03 0.66
Histology
 Adenocarcinoma 1 1
 Others 1.01 0.51-2.00 0.51 1.25 0.62-2.54 0.52
Surgery
 Wedge/Lobectomy 1 1
 Pneumonectomy 1.02 0.34-3.10 0.96 0.96 0.32-2.92 0.95
AdJuvant Treatment
 No 1 1
 Yes 0.60 0.19-1.87 0.19 0.95 0.30-2.91 0.92
TNM Stage
 II - IV 1 1
 I 0.28 0.11-0.72 0.00 0.32 0.12-0.82 0.02
CD8
 <950/mm² 1 1
 ≥950/mm² 0.28 0.12-0.65 0.00 0.47 0.21-1.03 0.06