Table 3.
Multivariate analysis of predictors of DFS and OS in PD-L1 negative NSCLC using the 25th percentile of CD8+ TILs (A) and in PD-L1 positive NSCLC using the 75th percentile of CD8+ TILs as threshold (B).
| Variables | DFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| A | ||||||
| Sex | ||||||
| Male | 1 | 1 | ||||
| Female | 0.62 | 0.38-1.02 | 0.06 | 0.57 | 0.33-0.98 | 0.04 |
| Age (years) | ||||||
| ≤70 | 1 | 1 | ||||
| >70 | 1.20 | 0.74-1.97 | 0.45 | 1.25 | 0.74-2.12 | 0.40 |
| Histology | ||||||
| Adenocarcinoma | 1 | 1 | ||||
| Others | 0.95 | 0.55-1.66 | 0.87 | 0.70 | 0.38-1.28 | 0.24 |
| Surgery | ||||||
| Wedge/Lobectomy | 1 | 1 | ||||
| Pneumonectomy | 0.36 | 0.11-1.20 | 0.09 | 0.64 | 0.19-2.16 | 0.48 |
| AdJuvant Treatment | ||||||
| No | 1 | 1 | ||||
| Yes | 1.04 | 0.54-1.20 | 0.91 | 1.12 | 0.56-2.23 | 0.74 |
| TNM Stage | ||||||
| II - IV | 1 | 1 | ||||
| I | 0.28 | 0.16-0.49 | 0.00 | 0.31 | 0.17-0.55 | 0.00 |
| CD8 | ||||||
| <300/mm² | 1 | 1 | ||||
| ≥300/mm² | 0.48 | 0.30-0.77 | 0.00 | 0.50 | 0.31-0.82 | 0.00 |
| B | ||||||
| Sex | ||||||
| Male | 1 | 1 | ||||
| Female | 0.91 | 0.38-2.21 | 0.84 | 0.66 | 0.24-1.83 | 0.43 |
| Age (years) | ||||||
| ≤70 | 1 | 1 | ||||
| >70 | 0.54 | 0.22-1.30 | 0.17 | 0.81 | 0.33-2.03 | 0.66 |
| Histology | ||||||
| Adenocarcinoma | 1 | 1 | ||||
| Others | 1.01 | 0.51-2.00 | 0.51 | 1.25 | 0.62-2.54 | 0.52 |
| Surgery | ||||||
| Wedge/Lobectomy | 1 | 1 | ||||
| Pneumonectomy | 1.02 | 0.34-3.10 | 0.96 | 0.96 | 0.32-2.92 | 0.95 |
| AdJuvant Treatment | ||||||
| No | 1 | 1 | ||||
| Yes | 0.60 | 0.19-1.87 | 0.19 | 0.95 | 0.30-2.91 | 0.92 |
| TNM Stage | ||||||
| II - IV | 1 | 1 | ||||
| I | 0.28 | 0.11-0.72 | 0.00 | 0.32 | 0.12-0.82 | 0.02 |
| CD8 | ||||||
| <950/mm² | 1 | 1 | ||||
| ≥950/mm² | 0.28 | 0.12-0.65 | 0.00 | 0.47 | 0.21-1.03 | 0.06 |