Table 3.
Bivariable and multivariable survival analysis.
| HR (95% CI) | ||
|---|---|---|
| Characteristic | Bivariable | Multivariable |
| Age, per year | 1.00 (0.99 - 1.02) | |
| Male sex | 0.77 (0.54 - 1.09) | 0.54 (0.38 - 0.78) |
| Disease duration, per year | 0.97 (0.95 - 1.00) | 0.97 (0.94 - 1.00) |
| Biologic order | ||
| First biologic | Ref. | |
| Second | 2.49 (0.97-6.38) | 3.62 (1.39-9.44) |
| Third | 2.77 (1.10-6.98) | 4.25 (1.66-10.93) |
| Fourth or more | 2.53 (0.99-6.44) | 5.09 (1.93-13.44) |
| csDMARD prior to Sec | 0.75 (0.52-1.09) | |
| Glucocorticoids | 2.00 (0.80-1.81) | |
| Obesity (BMI>30) | 0.49 (0.30-0.82) | 0.53 (0.30-0.93) |
| Smoker | 1.09 (0.87-1.35) | |
| Hypertension | 0.51 (0.34-0.77) | 0.55 (0.35-0.85) |
| Dyslipidemia | 0.87 (0.60-1.27) | |
| Diabetes | 0.29 (0.13-0.63) | 0.42 (0.18-0.99) |
| Cardiovascular disease* | 4.63 (0.64-33.39) | |
| Ischemic heart disease | 0.64 (0.26-1.58) | |
| Depression | 2.10 (1.38-3.21) | 2.53 (1.61-3.96) |
| Kidney failure | 1.40 (0.56-3.49) | |
| Hepatic failure | 1.09 (0.44-2.68) | |
*
Myocardial infarction or cerebrovascular event.