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. 2021 May 26;11:666734. doi: 10.3389/fonc.2021.666734

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Copyright © 2021 Wang, Banu, Canoll and Bruce

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative image of biopsy sites (white arrows) from both contrast-enhancing (upper) and non-enhancing (lower) regions, localized using stereotactic guidance with the BrainLab-registered wand indicating the biopsy site on preoperative MRI (green crosshairs). Note that both contrast-enhancing and non-enhancing biopsy sites demonstrate yellow-green fluorescence. Modified from Neira JA: Aggressive resection at the infiltrative margins of glioblastoma facilitated by intraoperative fluorescein guidance. Journal of Neurosurgery 127:111-122, 2017. With permission from Journal of Neurosurgery Publishing Group.