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. 2021 May 26;9:688388. doi: 10.3389/fcell.2021.688388

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Copyright © 2021 Alfaidi, Scott and Orr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PECAM-1 phosphorylation recruits Nck1 and Nck2 to endothelial cell-cell junctions. Nck1-dependent PAK activation promotes VE-cadherin phosphorylation and local myosin-dependent contractility to induce paracellular pore formation.