TABLE 2.

Some of the known Nck1/2 SH3 binding partners.

Binding partner	SH3 domain involved	Nck isoform	Proline rich sequence	Reference
PAK	SH3.2; less SH3.3	Nck1	KPPAPPMRNTSTM	Bokoch et al., 1996; Galisteo et al., 1996; Bokoch, 2003
WASP	SH3.1, SH3.2, SH3.3	Nck1	GRSGPXPPXP	Rivero-Lezcano et al., 1995
CYFIP2	SH3.1	Nck2	Uncharacterized	Lettau et al., 2010
FasL	SH3.2, less SH3.3	Nck2	PPLPLPPLKKR	Lettau et al., 2006
eIF beta	SH3.1, SH3.3	Nck1/2?	Uncharacterized	Kebache et al., 2002
Cortactin	SH3?	Nck1/2?	KPPVPPKP	Kruchten et al., 2008
CD3ε	SH3.1	Nck1/2?	NKERPPPVPNPDY	Sun et al., 2011
R-Ras	SH3.2; less SH3.3	Nck1/2?	PPSPPSAPRKK	Wang et al., 2000
SAM68	SH3.1	Nck1/2	Uncharacterized	Lawe et al., 1997
NIK	SH3	Nck2, not tested for Nck1	SODPCPPSRS/PRVPVRTTSR	Su et al., 1997

PAK, P21-activated kinase; WASP, Wiskott-Aldrich syndrome protein; CYFIP2, cytoplasmic FMR1-interacting protein 2; FasL, Fas ligand; TCR, T cell receptor; FAK, focal adhesion kinase; SAM68, SRC associated in mitosis of 68 kDa; NIK, Nck inducing kinase; SAPK, stress activated protein kinase; eIF, eukaryotic initiation factor.